Epidemiological characteristics of human metapneumovirus among children in Nanjing, China.
Eur J Clin Microbiol Infect Dis
; 43(7): 1445-1452, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38801487
ABSTRACT
PURPOSE:
The objective of this study was to examine the molecular epidemiology and clinical characteristics of HMPV infection among children with ARIs in Nanjing.METHODS:
The respiratory samples were collected from 2078 children (≤ 14 years) with acute respiratory infections and were tested for HMPV using real-time RT-PCR. Amplification and sequencing of the HMPV G gene were followed by phylogenetic analysis using MEGA 7.0.RESULT:
The detection rate of HMPV among children was 4.7% (97/2078), with a concentration in those under 5 years of age. Notably, the peak season for HMPV prevalence was observed in winter. Among the 97 HMPV-positive samples, 51.5% (50/97) were available for characterization of the HMPV G protein gene. Phylogenetic analysis indicated that the sequenced HMPV strains were classified into three sublineages A2c111nt - dup (84.0%), B1 (2.0%), and B2 (14.0%).CONCLUSION:
There was an incidence of HMPV among hospitalized children during 2021-2022 in Nanjing with A2c111nt - dup being the dominant strain. This study demonstrated the molecular epidemiological characteristics of HMPV among children with respiratory infections in Nanjing, China.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phylogeny
/
Respiratory Tract Infections
/
Seasons
/
Paramyxoviridae Infections
/
Molecular Epidemiology
/
Metapneumovirus
Limits:
Adolescent
/
Child
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Child, preschool
/
Female
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Humans
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Infant
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Male
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Newborn
Country/Region as subject:
Asia
Language:
En
Journal:
Eur J Clin Microbiol Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: