Your browser doesn't support javascript.
loading
Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target.
Fan, Yuxi; Xu, Ye; Huo, Zhi; Zhang, Hedong; Peng, Longkai; Jiang, Xin; Thomson, Angus W; Dai, Helong.
Affiliation
  • Fan Y; Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China.
  • Xu Y; Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Huo Z; Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Zhang H; Medical College of Guangxi University, Nanning, Guangxi 530004, China.
  • Peng L; Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China.
  • Jiang X; Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Thomson AW; Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Dai H; Department of Organ Transplantation, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou, Henan 450000, China.
Chin Med J (Engl) ; 137(14): 1663-1673, 2024 Jul 20.
Article in En | MEDLINE | ID: mdl-38809056
ABSTRACT
ABSTRACT Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival. TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders. More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases. There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease. This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury, renal fibrosis, diabetic nephropathy, immune nephropathy, and renal cell carcinoma.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Triggering Receptor Expressed on Myeloid Cells-1 / Kidney Diseases Limits: Animals / Humans Language: En Journal: Chin Med J (Engl) / Chin. med. j / Chinese medical journal Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Triggering Receptor Expressed on Myeloid Cells-1 / Kidney Diseases Limits: Animals / Humans Language: En Journal: Chin Med J (Engl) / Chin. med. j / Chinese medical journal Year: 2024 Document type: Article Affiliation country: Country of publication: