Garciyunnanones A-R: Caged polycyclic polyprenylated acylphloroglucinols decorated with a lavandulyl substituent from Garcinia yunnanensis.
Phytochemistry
; 224: 114167, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38810816
ABSTRACT
Garciyunnanones A-R (1-18), eighteen undescribed caged polycyclic polyprenylated acylphloroglucinols, two undescribed biogenetic congeners (19-20), and nineteen known analogues (21-39), were isolated from the stem barks of Garcinia yunnanensis Hu. All of these isolates are decorated with a C-5 lavandulyl substituent. Their structures and absolute configurations were confirmed by HRESIMS, 1D & 2D NMR spectroscopic analysis, quantum chemical calculations of electronic circular dichroism data, and single-crystal X-ray diffraction analysis. The X-ray crystallographic data of ten isolated caged compounds ascertained the absolute configuration of C-23 in the lavandulyl as S. The cytotoxicity on three cancer cell lines and the anti-nonalcoholic steatohepatitis activity of the isolates were tested. In a free fatty acid-induced L02 cell model, compounds 33 and 39 decreased intracellular lipid accumulation significantly.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phloroglucinol
/
Garcinia
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Country of publication: