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Isolation, structural determination, and antiviral activities of a novel alanine-conjugated polyketide from Talaromyces sp.
Mosu, Nozomi; Yasukochi, Mitsuki; Nakajima, Shogo; Nakamura, Kou; Ogata, Masaya; Iguchi, Keita; Kanno, Kazuki; Ishikawa, Tomohiro; Sugita, Kazutoshi; Murakami, Hironobu; Kuramochi, Kouji; Saito, Tatsuo; Takeda, Shiro; Watashi, Koichi; Fujino, Kan; Kamisuki, Shinji.
Affiliation
  • Mosu N; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Yasukochi M; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Nakajima S; Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
  • Nakamura K; Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
  • Ogata M; Choju Medical Institute, Yamanaka 19-14, Noyoricho, Toyohashi-shi, Aichi, 441-8124, Japan.
  • Iguchi K; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Kanno K; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Ishikawa T; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Sugita K; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Murakami H; Graduate School of Life Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-ku, Tokyo, 156-8502, Japan.
  • Kuramochi K; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Saito T; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Takeda S; Center for Human and Animal Symbiosis Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Watashi K; Department of Applied Biological Science, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
  • Fujino K; Department of Chemistry for Life Sciences and Agriculture, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-ku, Tokyo, 156-8502, Japan.
  • Kamisuki S; School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
J Antibiot (Tokyo) ; 77(8): 499-505, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38816448
ABSTRACT
Antiviral agents are highly sought after. In this study, a novel alkylated decalin-type polyketide, alaspelunin, was isolated from the culture broth of the fungus Talaromyces speluncarum FMR 16671, and its structure was determined using spectroscopic analyses (1D/2D NMR and MS). The compound was condensed with alanine, and its absolute configuration was determined using Marfey's method. Furthermore, the antiviral activity of alaspelunin against various viruses was evaluated, and it was found to be effective against both severe acute respiratory syndrome coronavirus 2 and pseudorabies (Aujeszky's disease) virus, a pathogen affecting pigs. Our results suggest that this compound is a potential broad-spectrum antiviral agent.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Talaromyces / Alanine / Polyketides Limits: Animals Language: En Journal: J Antibiot (Tokyo) Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Talaromyces / Alanine / Polyketides Limits: Animals Language: En Journal: J Antibiot (Tokyo) Year: 2024 Document type: Article Affiliation country: Country of publication: