The multiscale topological organization of the functional brain network in adolescent PTSD.
Cereb Cortex
; 34(6)2024 Jun 04.
Article
in En
| MEDLINE
| ID: mdl-38864573
ABSTRACT
The experience of an extremely aversive event can produce enduring deleterious behavioral, and neural consequences, among which posttraumatic stress disorder (PTSD) is a representative example. Although adolescence is a period of great exposure to potentially traumatic events, the effects of trauma during adolescence remain understudied in clinical neuroscience. In this exploratory work, we aim to study the whole-cortex functional organization of 14 adolescents with PTSD using a data-driven method tailored to our population of interest. To do so, we built on the network neuroscience framework and specifically on multilayer (multisubject) community analysis to study the functional connectivity of the brain. We show, across different topological scales (the number of communities composing the cortex), a hyper-colocalization between regions belonging to occipital and pericentral regions and hypo-colocalization in middle temporal, posterior-anterior medial, and frontal cortices in the adolescent PTSD group compared to a nontrauma exposed group of adolescents. These preliminary results raise the question of an altered large-scale cortical organization in adolescent PTSD, opening an interesting line of research for future investigations.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress Disorders, Post-Traumatic
/
Brain
/
Magnetic Resonance Imaging
Limits:
Adolescent
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Female
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Humans
/
Male
Language:
En
Journal:
Cereb Cortex
Journal subject:
CEREBRO
Year:
2024
Document type:
Article
Affiliation country: