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Elevated fecal calprotectin is associated with gut microbial dysbiosis, altered serum markers and clinical outcomes in older individuals.
Heinzel, Sebastian; Jureczek, Jenna; Kainulainen, Veera; Nieminen, Anni I; Suenkel, Ulrike; von Thaler, Anna-Katharina; Kaleta, Christoph; Eschweiler, Gerhard W; Brockmann, Kathrin; Aho, Velma T E; Auvinen, Petri; Maetzler, Walter; Berg, Daniela; Scheperjans, Filip.
Affiliation
  • Heinzel S; Department of Neurology, University Medical Centre Schleswig-Holstein (UKSH), Kiel, Germany. s.heinzel@neurologie.uni-kiel.de.
  • Jureczek J; Institute of Medical Informatics and Statistics, University Medical Centre Schleswig-Holstein (UKSH), Kiel, Germany. s.heinzel@neurologie.uni-kiel.de.
  • Kainulainen V; Department of Neurology, University Medical Centre Schleswig-Holstein, Kiel University, Arnold-Heller-Straße 3, 24105, Kiel, Germany. s.heinzel@neurologie.uni-kiel.de.
  • Nieminen AI; Department of Neurology, University Medical Centre Schleswig-Holstein (UKSH), Kiel, Germany.
  • Suenkel U; Institute of Medical Informatics and Statistics, University Medical Centre Schleswig-Holstein (UKSH), Kiel, Germany.
  • von Thaler AK; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Kaleta C; Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
  • Eschweiler GW; Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
  • Brockmann K; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Aho VTE; Department of Psychiatry and Psychotherapy, German Center of Mental Health, Tübingen University Hospital, Tübingen, Germany.
  • Auvinen P; Department of Neurology, University Medical Centre Schleswig-Holstein (UKSH), Kiel, Germany.
  • Maetzler W; Institute of Experimental Medicine, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany.
  • Berg D; Department of Psychiatry and Psychotherapy, German Center of Mental Health, Tübingen University Hospital, Tübingen, Germany.
  • Scheperjans F; Geriatric Center, University Hospital Tübingen, Tübingen, Germany.
Sci Rep ; 14(1): 13513, 2024 06 12.
Article in En | MEDLINE | ID: mdl-38866914
ABSTRACT
Fecal calprotectin is an established marker of gut inflammation in inflammatory bowel disease (IBD). Elevated levels of fecal calprotectin as well as gut microbial dysbiosis have also been observed in other clinical conditions. However, systemic and multi-omics alterations linked to elevated fecal calprotectin in older individuals remain unclear. This study comprehensively investigated the relationship between fecal calprotectin levels, gut microbiome composition, serum inflammation and targeted metabolomics markers, and relevant lifestyle and medical data in a large sample of older individuals (n = 735; mean age ± SD 68.7 ± 6.3) from the TREND cohort study. Low (0-50 µg/g; n = 602), moderate (> 50-100 µg/g; n = 64) and high (> 100 µg/g; n = 62) fecal calprotectin groups were stratified. Several pro-inflammatory gut microbial genera were significantly increased and short-chain fatty acid producing genera were decreased in high vs. low calprotectin groups. In serum, IL-17C, CCL19 and the toxic metabolite indoxyl sulfate were increased in high vs. low fecal calprotectin groups. These changes were partially mediated by the gut microbiota. Moreover, the high fecal calprotectin group showed increased BMI and a higher disease prevalence of heart attack and obesity. Our findings contribute to the understanding of fecal calprotectin as a marker of gut dysbiosis and its broader systemic and clinical implications in older individuals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Leukocyte L1 Antigen Complex / Feces / Dysbiosis / Gastrointestinal Microbiome Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Leukocyte L1 Antigen Complex / Feces / Dysbiosis / Gastrointestinal Microbiome Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: