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Prognostics of multiple malaria episodes and nutritional status in children aged 6 to 59 months from 2013 to 2017 in Dangassa, Koulikoro region, Mali.
Keita, Soumba; Thiero, Oumar; Toure, Mahamoudou; Kane, Fousseyni; Keita, Moussa; Sanogo, Ibrahim; Konate, Drissa; Sanogo, Daouda; Diawara, Sory Ibrahim; Coulibaly, Hamady; Thiam, Sidibé M 'Baye; Sogoba, Nafomon; Diakite, Mahamadou; Doumbia, Seydou.
Affiliation
  • Keita S; West African International Center for Excellence in Malaria Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. soumba.keita@icermali.org.
  • Thiero O; University Clinical Research Center (UCRC), University of Sciences, Techniques and Technologies of Bamako, UCRC-USTTB / Point-G, 1805, Bamako, Mali. soumba.keita@icermali.org.
  • Toure M; Malaria Research and Training Center (MRTC), University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. soumba.keita@icermali.org.
  • Kane F; West African International Center for Excellence in Malaria Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Keita M; Department of Health Research and Education, Faculty of Medicine and Odonto Stomatology, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
  • Sanogo I; West African International Center for Excellence in Malaria Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Konate D; University Clinical Research Center (UCRC), University of Sciences, Techniques and Technologies of Bamako, UCRC-USTTB / Point-G, 1805, Bamako, Mali.
  • Sanogo D; Malaria Research and Training Center (MRTC), University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Diawara SI; West African International Center for Excellence in Malaria Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Coulibaly H; University Clinical Research Center (UCRC), University of Sciences, Techniques and Technologies of Bamako, UCRC-USTTB / Point-G, 1805, Bamako, Mali.
  • Thiam SM'; Malaria Research and Training Center (MRTC), University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Sogoba N; West African International Center for Excellence in Malaria Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Diakite M; Malaria Research and Training Center (MRTC), University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • Doumbia S; West African International Center for Excellence in Malaria Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Malar J ; 23(1): 186, 2024 Jun 13.
Article in En | MEDLINE | ID: mdl-38872178
ABSTRACT

BACKGROUND:

In Africa, the relationship between childhood nutritional status and malaria remains complex and difficult to interpret. Understanding it is important in the improvement of malaria control strategies. This study aimed to assess the influence of nutritional status on the occurrence of multiple malaria episodes in children aged 6 to 59 months between 2013 and 2017 living in the village of Dangassa, Mali.

METHODS:

A community-based longitudinal study was conducted using cross-sectional surveys (CSSs) at the beginning (June) and end (November) of the malaria transmission season associated with passive case detection (PCD) at the Dangassa Community Health Centre. Children with asymptomatic malaria infection during cross-sectional surveys were selected and their malaria episodes followed by PCD. Malaria indicators in person-months were estimated using an ordinal-logistic model repeated on subjects during follow-up periods.

RESULTS:

The incidence rate (IR) during the period of high transmission (June to October), for 1 episode and for 2 + episodes peaked in 2013 with 65 children (IR = 95.73 per 1000 person-months) and 24 cases (IR = 35.35 per 1000 person-months), respectively. As expected, the risk of multiple episodes occurring during the period of high transmission was 3.23 compared to the period of low transmission after adjusting for other model parameters (95% CI [2.45-4.26], p = 0.000). Children with anaemia were at high risk of having multiple episodes (OR = 1.6, 95% CI [1.12-2.30], p = 0.011). However, the risk of having 2 + episodes for anemic children was higher during the period of low transmission (RR = 1.67, 95% CI [1.15-2.42], p = 0.007) compared to the period of high transmission (RR = 1.58, 95% CI [1.09-2.29], p = 0.016). The trend indicated that anemic and underweight children were significantly associated with multiple malaria episodes during the period of low transmission (p < 0.001).

CONCLUSION:

Results show that multiple episodes of malaria are significantly related to the nutritional status (anaemia and underweight) of the child during the two transmission seasons and more pronounced during the dry season (period of low transmission). Further research including other malnutrition parameters will be needed to confirm these findings.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nutritional Status / Malaria Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Africa Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nutritional Status / Malaria Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Africa Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2024 Document type: Article Affiliation country: Country of publication: