Exosomes Derived from Mesenchymal Stem Cells: Therapeutic Opportunities for Spinal Cord Injury.
Bull Exp Biol Med
; 176(6): 716-721, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38888648
ABSTRACT
Spinal cord injury (SCI) is a serious neurological condition comprising primary and secondary injury and causing severe neurological impairments. The effect of the conventional treatment is limited, including supportive therapy and emergency surgery. Exosomes derived from mesenchymal stem cells (MSCs-Exos) were previously reported to exert its potential therapeutic effects on SCI. Compared with mesenchymal stem cells (MSCs) transplantation for SCI, MSC-Exos showed several superiorities. In the present review, we summarized the revealed data of mechanisms underlying MSC-Exos repairing of SCI and discussed the issues of MSC-Exos use. Thus, in this review we summarized the latest studies on MSCs-Exos in the therapy of SCI and discussed whether MSCs-Exos can be applied to SCI and the prospects of transformation application.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord Injuries
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Mesenchymal Stem Cell Transplantation
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Exosomes
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Mesenchymal Stem Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Bull Exp Biol Med
Year:
2024
Document type:
Article
Affiliation country: