Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (SolowaysTM) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial.
Nutrients
; 16(11)2024 May 21.
Article
in En
| MEDLINE
| ID: mdl-38892484
ABSTRACT
Exploring the link between genetic polymorphisms in folate metabolism genes (MTHFR, MTR, and MTRR) and cardiovascular disease (CVD), this study evaluates the effect of B vitamin supplements (methylfolate, pyridoxal-5'-phosphate, and methylcobalamin) on homocysteine and lipid levels, potentially guiding personalized CVD risk management. In a randomized, double-blind, placebo-controlled trial, 54 patients aged 40-75 with elevated homocysteine and moderate LDL-C levels were divided based on MTHFR, MTR, and MTRR genetic polymorphisms. Over six months, they received either a combination of methylfolate, P5P, and methylcobalamin, or a placebo. At the 6 months follow-up, the treatment group demonstrated a significant reduction in homocysteine levels by 30.0% (95% CI -39.7% to -20.3%) and LDL-C by 7.5% (95% CI -10.3% to -4.7%), compared to the placebo (p < 0.01 for all). In the subgroup analysis, Homozygous Minor Allele Carriers showed a more significant reduction in homocysteine levels (48.3%, 95% CI -62.3% to -34.3%, p < 0.01) compared to mixed allele carriers (18.6%, 95% CI -25.6% to -11.6%, p < 0.01), with a notable intergroup difference (29.7%, 95% CI -50.7% to -8.7%, p < 0.01). LDL-C levels decreased by 11.8% in homozygous carriers (95% CI -15.8% to -7.8%, p < 0.01) and 4.8% in mixed allele carriers (95% CI -6.8% to -2.8%, p < 0.01), with a significant between-group difference (7.0%, 95% CI -13.0% to -1.0%, p < 0.01). Methylfolate, P5P, and methylcobalamin supplementation tailored to genetic profiles effectively reduced homocysteine and LDL-C levels in patients with specific MTHFR, MTR, and MTRR polymorphisms, particularly with homozygous minor allele polymorphisms.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridoxal Phosphate
/
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Vitamin B 12
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Tetrahydrofolates
/
Dietary Supplements
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Methylenetetrahydrofolate Reductase (NADPH2)
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Ferredoxin-NADP Reductase
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Homocysteine
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Cholesterol, LDL
Limits:
Adult
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Aged
/
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Nutrients
Year:
2024
Document type:
Article
Affiliation country: