Cardiovascular disease therapeutics via engineered oral microbiota: Applications and perspective.

Zhen, Wenyu; Wang, Zifei; Wang, Qing; Sun, Wansu; Wang, Rui; Zhang, Wenhao; Zhang, Yulong; Qin, Wengang; Li, Bang; Wang, Qingqing; Hong, Biao; Yang, Yicheng; Xu, Jing; Ma, Siyu; Da, Ming; Feng, Linfei; Zang, Xiaodong; Mo, Xuming; Sun, Xiaoyu; Wu, Mingyue; Xu, Junji; Xu, Jianguang; Huang, Yuan; Zhang, Hengguo

Zhen, Wenyu; Wang, Zifei; Wang, Qing; Sun, Wansu; Wang, Rui; Zhang, Wenhao; Zhang, Yulong; Qin, Wengang; Li, Bang; Wang, Qingqing; Hong, Biao; Yang, Yicheng; Xu, Jing; Ma, Siyu; Da, Ming; Feng, Linfei; Zang, Xiaodong; Mo, Xuming; Sun, Xiaoyu; Wu, Mingyue; Xu, Junji; Xu, Jianguang; Huang, Yuan; Zhang, Hengguo.

Affiliation

Zhen W; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Wang Z; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Wang Q; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Sun W; Department of Stomatology The First Affiliated Hospital of Anhui Medical University Hefei China.
Wang R; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Zhang W; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Zhang Y; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Qin W; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei China.
Li B; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Wang Q; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Hong B; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Yang Y; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Pediatric Cardiac Surgery Center, Fuwai Hospital Chinese Academy of Medical Sciences, and Peking Union Medical College Beijing China.
Xu J; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Pediatric Cardiac Surgery Center, Fuwai Hospital Chinese Academy of Medical Sciences, and Peking Union Medical College Beijing China.
Ma S; Department of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing China.
Da M; Department of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing China.
Feng L; Department of Stomatology The First Affiliated Hospital of Anhui Medical University Hefei China.
Zang X; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei China.
Mo X; Department of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing China.
Sun X; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Wu M; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Xu J; Laboratory of Tissue Regeneration and Immunology, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Department of Periodontics, School of Stomatology Capital Medical University Beijing China.
Xu J; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Huang Y; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Pediatric Cardiac Surgery Center, Fuwai Hospital Chinese Academy of Medical Sciences, and Peking Union Medical College Beijing China.
Zhang H; Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.

Imeta ; 3(3): e197, 2024 Jun.

Article in En | MEDLINE | ID: mdl-38898992

ABSTRACT

ABSTRACT

Engineering bacteria are considered as a potential treatment for cardiovascular diseases and related risk factors. Oral bacteria are closely related to the occurrence and development of cardiovascular diseases, and their engineering has broad prospects and potential in the treatment of cardiovascular diseases. Oral pathogenic bacteria undergo protein and genetic engineering, including the incorporation of exogenous plasmids to yield therapeutic effects; genetically engineered oral probiotics can be harnessed to secrete cytokines and reactive oxygen species, offering novel therapeutic avenues for cardiovascular diseases.

Key words

cardiovascular diseases; engineered microbiota; oral microbiota

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