Intraoperative urinary tract resection and construction in CRS + HIPEC procedures: a single center retrospective analysis.
World J Surg Oncol
; 22(1): 171, 2024 Jun 26.
Article
in En
| MEDLINE
| ID: mdl-38926860
ABSTRACT
INTRODUCTION:
The safety and efficacy of CRS + HIPEC combined with urinary tract resection and reconstruction are controversial. This study aims to summarize the clinicopathological features and to evaluate the safety and survival prognosis of CRS + HIPEC combined with urinary tract resection and reconstruction.METHODS:
The patients who underwent urinary tract resection and reconstruction as part of CRS surgery were retrospectively selected from our disease-specific database for analysis. The clinicopathological characteristics, treatment-related variables, perioperative adverse events (AEs), and survival outcomes were studied using a descriptive approach and the K-M analysis with log-rank comparison.RESULTS:
Forty-nine patients were enrolled. Perioperative serious AEs (SAEs) were observed in 11 patients (22.4%), with urinary SAEs occurring in 3 patients (6.1%). Additionally, there were 23 cases (46.8%) involving urinary adverse events (UAEs). The median overall survival (OS) in the entire cohort was 59.2 (95%CI 42.1-76.4) months. The median OS of the UAE group and No-UAE group were 59.2 months (95%CI not reached), and 50.5 (95%CI 11.5 to 89.6) months, respectively, with no significant difference (P = 0.475). Furthermore, there were no significant differences in OS based on the grade of UAEs or the number of UAEs (P = 0.562 and P = 0.622, respectively).CONCLUSION:
The combination of CRS + HIPEC with urinary tract resection and reconstruction is associated with a high incidence of Grade I-II UAEs, which do not have an impact on OS. The safety profile of this combined technique is acceptable. However, this is a retrospective single-center single-arm analysis, with limitations of generalizability and potential selection bias. The findings need high-level validation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytoreduction Surgical Procedures
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Hyperthermic Intraperitoneal Chemotherapy
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Hyperthermia, Induced
Limits:
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
World J Surg Oncol
Year:
2024
Document type:
Article