Impact of obesityassociated myeloidderived suppressor cells on cancer risk and progression (Review).
Int J Oncol
; 65(2)2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38940351
ABSTRACT
Obesity is a chronic disease caused by the accumulation of excessive adipose tissue. This disorder is characterized by chronic lowgrade inflammation, which promotes the release of proinflammatory mediators, including cytokines, chemokines and leptin. Simultaneously, chronic inflammation can predispose to cancer development, progression and metastasis. Proinflammatory molecules are involved in the recruitment of specific cell populations in the tumor microenvironment. These cell populations include myeloidderived suppressor cells (MDSCs), a heterogeneous, immature myeloid population with immunosuppressive abilities. Obesityassociated MDSCs have been linked with tumor dissemination, progression and poor clinical outcomes. A comprehensive literature review was conducted to assess the impact of obesityassociated MDSCs on cancer in both preclinical models and oncological patients with obesity. A secondary objective was to examine the key role that leptin, the most important proinflammatory mediator released by adipocytes, plays in MDSCdriven immunosuppression Finally, an overview is provided of the different therapeutic approaches available to target MDSCs in the context of obesityrelated cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Disease Progression
/
Tumor Microenvironment
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Myeloid-Derived Suppressor Cells
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Neoplasms
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Obesity
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Oncol
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: