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Experimental and computational assessment of Antiparkinson Medication effects on meiofauna: Case study of Benserazide and Trihexyphenidyl.
Ishak, Sahar; Allouche, Mohamed; Alotaibi, Ghadah S; Alwthery, Nada S; Al-Subaie, Raghad A; Al-Hoshani, Nawal; Plavan, Oana-Alexandra; Selamoglu, Zeliha; Özdemir, Sadin; Plavan, Gabriel; Badraoui, Riadh; Rudayni, Hassan A; Boufahja, Fehmi.
Affiliation
  • Ishak S; LR01ES14 Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna 7021, Tunisia.
  • Allouche M; LR01ES14 Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna 7021, Tunisia; Biology Department, Higher Institute of Biotechnology of Beja, University of Jendouba, 9000, BP: 382, Tunisia.
  • Alotaibi GS; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia. Electronic address: 440028651@sm.imamu.edu.sa.
  • Alwthery NS; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia. Electronic address: 440025284@sm.imamu.edu.sa.
  • Al-Subaie RA; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia. Electronic address: 441021987@sm.imaum.edu.sa.
  • Al-Hoshani N; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: nialhoshani@pnu.edu.sa.
  • Plavan OA; Department of Environmental Engineering and Management, Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, Iasi, Romania. Electronic address: oana.plavan@tuaisi.ro.
  • Selamoglu Z; Department of Medical Biology, Medicine Faculty, Nigde Omer Halisdemir University, Nigde, Turkey. Electronic address: zselamoglu@ohu.edu.tr.
  • Özdemir S; Food Processing Programme Technical Science Vocational School Mersin University, TR-33343 Yenisehir, Mersin, Turkey. Electronic address: sadinozdemir@mersin.edu.tr.
  • Plavan G; Department of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University, Bvd. Carol I, No. 20A, 700505, Iasi, Romania. Electronic address: gabriel.plavan@uaic.ro.
  • Badraoui R; Department of Biology, Laboratory of General Biology, College of Science, University of Ha'il, Ha'il 81451, Saudi Arabia; Section of Histology-Cytology & Cytogenetics, Faculty of Medicine of Tunis, University of Tunis El Manar, 1007 La Rabta-Tunis, Tunisia. Electronic address: riadh.badraoui@fmt
  • Rudayni HA; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia. Electronic address: harudayni@imamu.edu.sa.
  • Boufahja F; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia. Electronic address: faboufahja@imamu.edu.sa.
Mar Pollut Bull ; 205: 116668, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38972217
ABSTRACT
Two concentrations (6.25 and 1.25 mg/L) were used for two Parkinson's disease medications, Benserazide, and Trihexyphenidyl, to test their effects on the meiobenthic nematofauna. It is predicted that these highly hydrosoluble drugs will end up in marine environments. The results showed that both medications when added alone, induced (i) important changes in the numbers and (ii) taxonomic composition. The impact of Benserazide and Trihexyphenidyl was also reflected in the (iii) functional traits of nematofauna, with the most affected categories following exposure being the trophic group 1B, the clavate tails, the circular amphids, the c-p2 life history, and the body length of 1-2 mm. These results were supported by the molecular interactions of the studied drugs with both GLD-3 and SDP proteins of Caenorhabditis elegans. (iv) The mixtures of both drugs did not show any changes in the nematode communities, suggesting that no synergistic or antagonistic interactions exist between them.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benserazide / Trihexyphenidyl / Caenorhabditis elegans / Antiparkinson Agents Limits: Animals Language: En Journal: Mar Pollut Bull Year: 2024 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benserazide / Trihexyphenidyl / Caenorhabditis elegans / Antiparkinson Agents Limits: Animals Language: En Journal: Mar Pollut Bull Year: 2024 Document type: Article Affiliation country: