[Molecular allergen IgE tests show neosensitizaions occurring during house dust mite specific immunotherapy].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 38(7): 572-577, 2024 Jul.
Article
in Zh
| MEDLINE
| ID: mdl-38973033
ABSTRACT
Objective:
Neosensitizations may be occur during the allergen specific immunotherapyï¼AITï¼ due to the differences between allergen vaccine's content and a patient's molecular sensitization profile. This study investigates whether AIT with HDM extract changes the sensitization profile, whether de novo sensitization occurs, and the clinical importance of the neosensitization.Methods:
Fifty-three patients with HDM allergic rhinitis ,with/without asthma, patients were received one year HDM subcutaneous AIT . Fourteen patients were recruited as control group and received only necessary medications. Serum samples were collected at baseline, 6îthmoths and 12îthof AIT, respectively. Serum samples were tested specific IgE against Der p, Der p 1/2/3 and Der f, Der f 1/2/3, as well as IgG4 against Der p, Der p 1/2 and Der f, Der f 1/2. VAS were collected at the time-points as well.Results:
In AIT group, Der p, Der p 1/3, and Der f 1/3 specific IgE levels were significantly higher after one-year treatment, especially for Der p 3. There were 69.2%ï¼18/26ï¼ patients whose Der p 3 specific IgE below 0.35 kU/L at baseline but became positiveï¼>0.35 kU/Lï¼ after treatment, that is, neosensitization occurred. All tested allergen specific IgG4 level significantly increased after one year AIT treatment and the VAS declined dramatically. However, for patients with neosensitization and without neosensitization, there were no significantly changes concerning to IgG4 level and VAS.Conclusion:
Patients undergoing AIT might have a risk of neosensitization to the allergen components in the vaccines. However, the clinical importance of the neosensitization remains unclear and warrants further studies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin E
/
Allergens
/
Desensitization, Immunologic
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Pyroglyphidae
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Antigens, Dermatophagoides
Limits:
Adult
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Animals
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Female
/
Humans
/
Male
Language:
Zh
Journal:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Year:
2024
Document type:
Article
Country of publication: