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ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis.
Zhang, Lu; Feng, Qianqian; Kong, Wei.
Affiliation
  • Zhang L; Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Feng Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
  • Kong W; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Physiology (Bethesda) ; 39(5): 0, 2024 09 01.
Article in En | MEDLINE | ID: mdl-38984789
ABSTRACT
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Extracellular Matrix / Homeostasis Limits: Animals / Humans Language: En Journal: Physiology (Bethesda) Journal subject: FISIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Extracellular Matrix / Homeostasis Limits: Animals / Humans Language: En Journal: Physiology (Bethesda) Journal subject: FISIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: