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Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.
Markowska, Anna; de Mezer, Mateusz; Kurzawa, Pawel; Bednarek, Wieslawa; Grybos, Anna; Krzyzaniak, Monika; Markowska, Janina; Grybos, Marian; Zurawski, Jakub.
Affiliation
  • Markowska A; Department of Perinatology and Women's Diseases, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
  • de Mezer M; Medical Biology, Department of Immunobiology, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
  • Kurzawa P; Department of Clinical Pathology and Immunology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
  • Bednarek W; Department of Oncological Pathology, University Clinical Hospital in Poznan, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
  • Grybos A; Department of Oncological Gynecology and Gynecology, Medical University of Lublin, 20-059 Lublin, Poland.
  • Krzyzaniak M; Department of Gynecology and Obstetrics, Faculty of Health Sciences, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Markowska J; Department of Clinical Pathology and Immunology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
  • Grybos M; Department of Oncological Pathology, University Clinical Hospital in Poznan, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
  • Zurawski J; Gynecological Center, 60-560 Poznan, Poland.
Int J Mol Sci ; 25(13)2024 Jun 28.
Article in En | MEDLINE | ID: mdl-39000274
ABSTRACT
Understanding the molecular factors involved in the development of uterine myomas may result in the use of pharmacological drugs instead of aggressive surgical treatment. ANG1, CaSR, and FAK were examined in myoma and peripheral tissue samples taken from women after myoma surgery and in normal uterine muscle tissue samples taken from the control group. Tests were performed using tissue microarray immunohistochemistry. No statistically significant differences in ANG1 expression between the tissue of the myoma, the periphery, and the normal uterine muscle tissue of the control group were recorded. The CaSR value was reduced in the myoma and peripheral tissue and normal in the group of women without myomas. FAK expression was also lower in the myoma and periphery compared to the healthy uterine myometrium. Calcium supplementation could have an effect on stopping the growth of myomas.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Neoplasms / Receptors, Calcium-Sensing / Focal Adhesion Kinase 1 / Leiomyoma Limits: Adult / Female / Humans / Middle aged Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Neoplasms / Receptors, Calcium-Sensing / Focal Adhesion Kinase 1 / Leiomyoma Limits: Adult / Female / Humans / Middle aged Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country: