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Health-related quality of life with comprehensive geriatric assessment guided care versus usual care in older adults with cancer: A systematic review and meta-analysis of randomized trials.
Ng, Zhi Xuan; Handa, Pooja; Zheng, Huili; Chen, Matthew Zhixuan; Soon, Yu Yang; Blinman, Prunella; Stockler, Martin; Ho, Francis.
Affiliation
  • Ng ZX; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore.
  • Handa P; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore.
  • Zheng H; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
  • Chen MZ; Division of Geriatric Medicine, Department of Medicine, National University Hospital, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Soon YY; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia. Electronic address: yysoon01
  • Blinman P; Department of Medical Oncology, Concord Repatriation General Hospital, Sydney, NSW, Australia.
  • Stockler M; NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia; Department of Medical Oncology, Concord Repatriation General Hospital, Sydney, NSW, Australia; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, NSW, Australia.
  • Ho F; Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Crit Rev Oncol Hematol ; 201: 104442, 2024 Sep.
Article in En | MEDLINE | ID: mdl-39002788
ABSTRACT

BACKGROUND:

To evaluate if comprehensive geriatric assessment (CGA)-guided care improves health-related quality of life (HRQL) in older adults with cancer compared to usual care.

METHODS:

Relevant randomized controlled trials (RCTs) were identified through biomedical databases. Meta-analyses using DerSimonian-Laird model summarized the difference in the mean change of HRQL scores from baseline across various time points, with evidence certainty assessed by the GRADE tool. Logistic regression via generalized estimating equations analyzed predictors of HRQL improvement.

RESULTS:

Potential improvement in the global HRQL score by CGA-guided care at 3 months (Cohen's d 0.27, 95 % CI -0.03-0.58, moderate certainty), could not be excluded. Larger RCTs or those mandating CGA before initiating anti-cancer treatment were predictors of improved HRQL.

CONCLUSION:

The effects of CGA-guided care on HRQL were variable. Larger RCTs and those mandating pre-treatment CGA tended to report improved HRQL.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quality of Life / Geriatric Assessment / Randomized Controlled Trials as Topic / Neoplasms Limits: Aged / Aged80 / Humans Language: En Journal: Crit Rev Oncol Hematol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quality of Life / Geriatric Assessment / Randomized Controlled Trials as Topic / Neoplasms Limits: Aged / Aged80 / Humans Language: En Journal: Crit Rev Oncol Hematol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication: