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Mature tertiary lymphoid structures: important contributors to anti-tumor immune efficacy.
Bao, Xinyu; Lin, Xuwen; Xie, Mei; Yao, Jie; Song, Jialin; Ma, Xidong; Zhang, Xin; Zhang, Yinguang; Liu, Yiming; Han, Wenya; Liang, Yiran; Hu, Hongling; Xu, Li; Xue, Xinying.
Affiliation
  • Bao X; Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
  • Lin X; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Xie M; Department of Respiratory and Critical Care, Chinese PLA General Hospital, Beijing, China.
  • Yao J; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Song J; Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
  • Ma X; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Zhang X; Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
  • Zhang Y; Department of Thoracic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Liu Y; Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China.
  • Han W; Department of Respiratory and Critical Care, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
  • Liang Y; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Hu H; Department of Respiratory Medicine, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xu L; Department of Respiratory Endoscopy, The Public Health Clinical Center Affiliated of Shandong University, Jinan, China.
  • Xue X; Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Front Immunol ; 15: 1413067, 2024.
Article in En | MEDLINE | ID: mdl-39026670
ABSTRACT
Tertiary lymphoid structures (TLS) represent the ectopic aggregations of immune cells arising during chronic inflammation or tumor progression. In cancer, TLS are often associated with beneficial clinical outcomes in patients undergoing immunotherapy, underscoring their prognostic and predictive significance. Mature TLS, characterized by germinal centers and areas of T-cell and B-cell aggregation, are considered primary locations for activating and maintaining both humoral and cellular anti-tumor immune effects. Despite their recognized importance, the mechanisms driving the formation of mature TLS in cancer and their influence on the immune response within tumors remain insufficiently understood. Therefore, this review aims to comprehensively explore the structural composition, development mechanisms, maturity impact factors, immunological function, and innovative therapeutic strategies of mature TLS within the tumor microenvironment. The research summarized herein offers novel insights and considerations for therapeutic approaches to promote TLS generation and maturation in patients with cancer, representing a promising avenue for future cancer therapies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Microenvironment / Tertiary Lymphoid Structures / Neoplasms Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Microenvironment / Tertiary Lymphoid Structures / Neoplasms Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2024 Document type: Article Affiliation country: Country of publication: