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Characterizing Rare Dormant and Cycling Lineages Using the Watermelon System.
Handly-Santana, Abram; Oren, Yaara.
Affiliation
  • Handly-Santana A; NGM Bio, San Francisco, CA, USA.
  • Oren Y; Department of Human Molecular Genetics & Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. yoren@tauex.tau.ac.il.
Methods Mol Biol ; 2811: 165-175, 2024.
Article in En | MEDLINE | ID: mdl-39037657
ABSTRACT
Barcode-based lineage tracing approaches enable molecular characterization of clonal cell families. Barcodes that are expressed as mRNA can be used to deconvolve lineage identity from single-cell RNA sequencing transcriptional data. Here we describe the Watermelon system, which facilitates the simultaneous tracing of lineage, transcriptional, and proliferative state at a single cell level.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Lineage / Single-Cell Analysis Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Lineage / Single-Cell Analysis Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: Country of publication: