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Lactate/lactylation in ocular development and diseases.
Chai, Peiwei; Zhao, Fei; Jia, Renbing; Zhou, Xiangtian; Fan, Xianqun.
Affiliation
  • Chai P; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, People's Republic of China.
  • Zhao F; State Key Laboratory of Ophthalmology, Optometry, and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; Oujiang Laboratory, Zheji
  • Jia R; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, People's Republic of China. Electronic address: renbingjia@sjtu.edu
  • Zhou X; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, People's Republic of China. Electronic address: zhouxt@shsmu.edu.cn
  • Fan X; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, People's Republic of China. Electronic address: fanxq@sjtu.edu.cn.
Trends Mol Med ; 2024 Jul 24.
Article in En | MEDLINE | ID: mdl-39054226
ABSTRACT
Lactylation, a post-translational modification (PTM) induced by lactate, has crucial roles in the regulation of transcription, DNA repair, and mitochondrial metabolism. Here, we discuss the role of lactate/lactylation signaling in regulating eye morphogenesis and retinal homeostasis, as well as various ophthalmic disorders, such as myopia, intraocular malignancies, and retinal angiogenesis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Trends Mol Med / Trends in molecular medicine / Trends mol. med Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Trends Mol Med / Trends in molecular medicine / Trends mol. med Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Country of publication: