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Tertiary lymphoid structures as potential biomarkers for cancer prediction and prognosis.
Zhang, Xin; Yao, Jie; Xie, Mei; Liang, Yiran; Lin, Xuwen; Song, Jialin; Bao, Xinyu; Ma, Xidong; Wang, Yuanyong; Zhang, Yinguang; Liu, Yiming; Han, Wenya; Pan, Lei; Xue, Xinying.
Affiliation
  • Zhang X; School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, China.
  • Yao J; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
  • Xie M; Department of Respiratory and Critical Care, Chinese PLA General Hospital, Beijing, 100835, China.
  • Liang Y; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
  • Lin X; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
  • Song J; School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, China.
  • Bao X; School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, China.
  • Ma X; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
  • Wang Y; Department of Thoracic Surgery, Tangdu Hospital of Air Force Military Medical University, Xi'an, Shanxi, 710038, China.
  • Zhang Y; Department of Thoracic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Liu Y; Department of Respiratory and Critical Care, Chinese PLA General Hospital, Beijing, 100835, China.
  • Han W; Department of Respiratory and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.
  • Pan L; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. Electronic address: leipan2010@163.com.
  • Xue X; School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, China; Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. Electronic address: xuexinying298
Int Immunopharmacol ; 140: 112790, 2024 Jul 31.
Article in En | MEDLINE | ID: mdl-39088920
ABSTRACT
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates formed in non-lymphoid tissues, including cancers, and are loci for the generation of in situ anti-tumor immune responses, which play a crucial role in cancer control. The state of TLS presence in cancer and its composition can significantly impact the treatment response and prognosis of patients. TLSs have the potential to serve as predictive and prognostic biomarkers for cancer. However, the mechanisms underlying TLS formation in cancer and how the essential components of TLSs affect cancer are not fully understood. In this review, we summarized TLS formation in cancer, the value of the TLS in different states of existence, and its key constituents for cancer prediction and prognosis. Finally, we discussed the impact of cancer treatment on TLSs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2024 Document type: Article Affiliation country:
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: