The association of the room air challenge with long-term outcomes in extremely preterm infants.
J Perinatol
; 44(9): 1300-1306, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39095524
ABSTRACT
OBJECTIVE:
Evaluate the association between results of the room air (RA) challenge and death, respiratory morbidity, and neurodevelopmental impairment (NDI) at 2 years' corrected age. STUDYDESIGN:
Cohort study of infants born <27 weeks' gestational age who underwent a RA challenge to determine BPD diagnosis at 36 weeks postmenstrual age.RESULTS:
Of 1022 infants eligible for the RA challenge, 554 underwent testing and 223 passed. Test result was not associated with death or serious respiratory morbidities [adjusted relative risk (aRR) 1.01, 95% confidence interval (CI) 0.65-1.56] or death or moderate/severe NDI (aRR 1.06, 95% CI 0.81-1.39) at 2 years.CONCLUSION:
Results of the RA challenge were not associated with differences in respiratory or neurodevelopmental morbidity at 2 years, suggesting the RA challenge does not add prognostic value in contemporary extremely preterm infants. GOV ID Generic Database NCT00063063.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gestational Age
/
Infant, Extremely Premature
Limits:
Child, preschool
/
Female
/
Humans
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Infant
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Male
/
Newborn
Language:
En
Journal:
J Perinatol
/
J. perinatol
/
Journal of perinatology
Journal subject:
PERINATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: