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When metabolic comorbidities and risk of malnutrition coexist: The new era of inflammatory bowel disease.
García-Mateo, Sandra; Martínez-Domínguez, Samuel Jesús; Gargallo-Puyuelo, Carla Jerusalén; Villarino, María Teresa Arroyo; Laredo, Viviana; Gallego, Beatriz; Alfambra, Erika; Sanz, Borja; Gomollón, Fernando.
Affiliation
  • García-Mateo S; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain; School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain. Electronic address: sgarciamat@salud.aragon.es.
  • Martínez-Domínguez SJ; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain; School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
  • Gargallo-Puyuelo CJ; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain; School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
  • Villarino MTA; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain; School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
  • Laredo V; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Gallego B; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Alfambra E; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Sanz B; Department of Endocrinology, Manises Hospital, 46940 Valencia, Spain.
  • Gomollón F; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain; School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
Am J Med Sci ; 2024 Aug 02.
Article in En | MEDLINE | ID: mdl-39098709
ABSTRACT

BACKGROUND:

Metabolic dysfunction-associated steatotic liver disease (MASLD) and risk of malnutrition can coexist in patients with inflammatory bowel disease (IBD). We performed a malnutrition risk assessment as part of the standard follow-up of IBD patients and studied the potential risk factors for being at risk of malnutrition based on the presence or absence of MASLD.

METHODS:

The Malnutrition Universal Screening Tool (MUST) was used to screen malnutrition risk (MUST ≥1) and controlled attenuation parameter (CAP ≥248 dB/min) to assess MASLD. Adherence to a Mediterranean diet, physical activity, and quality of life were also assessed.

RESULTS:

Of 686 evaluated IBD patients, 130 (18.9 %) were identified as being at risk of malnutrition. Patients without MASLD (n = 89 [68.5 %]) were more likely to be at risk than those with MASLD (n = 41 [31.5 %], p = 0.005). However, among patients at risk of malnutrition, those with MASLD were more likely to have active IBD (82.9 %) than patients without MASLD (39.3 %, p < 0.001). Female sex (OR 1.984, p = 0.027) and young age (OR 1.014, p = 0.006) were associated with malnutrition risk only in patients with IBD without MASLD. Being at risk of malnutrition was associated with worse quality of life (p < 0.001), especially in IBD patients with MASLD.

CONCLUSIONS:

Malnutrition risk and quality of life are modified by the presence of MASLD in IBD patients.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Am J Med Sci Year: 2024 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Am J Med Sci Year: 2024 Document type: Article Country of publication: