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Confined migration: Microtubules control the cell rear.
Thery, Manuel; Akhmanova, Anna.
Affiliation
  • Thery M; CytoMorpho Lab, LPCV, UMR5168, Université Grenoble-Alpes, CEA/INRA/CNRS, Interdisciplinary Research Institute of Grenoble, 17 rue des Martyrs, 38054 Grenoble, France; CytoMorpho Lab, CBI, UMR8132, Université Paris Sciences et Lettres, Ecole Supérieure de Physique et Chimie Industrielles de la Ville de Paris, CEA/CNRS, Institut Pierre Gilles De Gennes, 6 rue Jean Calvin, 75005 Paris, France. Electronic address: manuel.thery@cea.fr.
  • Akhmanova A; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 Utrecht, The Netherlands. Electronic address: a.akhmanova@uu.nl.
Curr Biol ; 34(15): R728-R731, 2024 Aug 05.
Article in En | MEDLINE | ID: mdl-39106829
ABSTRACT
Cell migration through complex 3D environments relies on the interplay between actin and microtubules. A new study shows that, when cells pass through narrow constrictions, CLASP-dependent microtubule stabilisation at the cell rear controls actomyosin contractility to enable nuclear translocation and preserve cell integrity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Microtubules Limits: Animals Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2024 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Microtubules Limits: Animals Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2024 Document type: Article Country of publication: