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Anti-amyloid aggregation and anti-hyperglycemic activities of novel ruthenium uracil Schiff base compounds.
Makanyane, Daniel M; Mabuza, Lindokuhle P; Ngubane, Phikelelani; Khathi, Andile; Mambanda, Allen; Booysen, Irvin Noel.
Affiliation
  • Makanyane DM; University of KwaZulu-Natal - Pietermaritzburg Campus, Chemistry, SOUTH AFRICA.
  • Mabuza LP; University of KwaZulu-Natal - Westville Campus, Human Physiology, SOUTH AFRICA.
  • Ngubane P; University of KwaZulu-Natal - Westville Campus, Human Physiology, SOUTH AFRICA.
  • Khathi A; University of KwaZulu-Natal - Westville Campus, Human Physiology, SOUTH AFRICA.
  • Mambanda A; University of KwaZulu-Natal - Pietermaritzburg Campus, Chemistry, SOUTH AFRICA.
  • Booysen IN; University of KwaZulu-Natal, Chemistry, Corner of Golf and Ridge Roads, Scottsville, 3260, Pietermaritzburg, SOUTH AFRICA.
ChemMedChem ; : e202400477, 2024 Aug 13.
Article in En | MEDLINE | ID: mdl-39136611
ABSTRACT
The formation and characterization of new diamagnetic ruthenium uracil mono-imine compounds [(η6-p-cymene)RuII(L)Cl][BF4] (L = H2urpda = 5-((pyridin-2-yl)methyleneamino)-6-aminouracil) for 1, urdpy = 6-amino-1,3-dimethyl-5-((pyridin-2-ylmethylene)amino)uracil) for 2 or urqda = 5-((quinolin-2-yl)methyleneamino)-6-aminouracil) for 3); cis-[RuII(L)(bipy)2] (L =  urpy = 5-((pyridin-2-yl)methyleneamino)uracil) for 4 and H2dadp = 5,6-diaminouracil for 5) are described. A paramagnetic ruthenium uracil Schiff base compound,  trans-[RuIV(L)(PPh3)Cl2] (L = H2urpda for 6) was also formed. Various physicochemical techniques were utilized to characterize the novel ruthenium compounds. Similarly, the stabilities of 1 - 3 and 6 monitored in chloro-containing and the non-coordinating solvent, dichloromethane show that they are kinetically inert, whereas, in a high nucleophilic environment, the chloride co-ligands of these ruthenium complexes were rapidly substituted by DMSO. In contrast, the substitution of the labile co-ligands for these ruthenium complexes by DMSO molecules in a high chloride content was suppressed. Solution chemical reactivities of the different ruthenium complexes were rationalized by density functional theory computations. Furthermore, the binding affinities and strengths between BSA and the respective ruthenium complexes were monitored using fluorescence spectroscopy. In addition, the in vitro anti-diabetic activities of the novel metal complexes were assessed in selected skeletal muscle and liver cell lines.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication: