Targeting Divergent Pathways in the Nutritional Management of Depression.
Nutrients
; 16(16)2024 Aug 22.
Article
in En
| MEDLINE
| ID: mdl-39203943
ABSTRACT
The nutritional management of depression has long been discussed, due to the perceived benefit of a nutritional product having less side effects than pharmaceutical agents. Candidate nutrients for managing depression include vitamin D, B vitamins, tryptophan, branch chain amino acids, probiotics, omega-3 fatty acids, folate/methylfolate (also known as vitamin B9), and s-adenosylmethionine. This paper provides a narrative review of three nutrients which have significant scientific support for the management of depression. A deficiency in each nutrient is associated with depression, and interventional studies indicate that the correction of the nutritional deficiency may provide clinical benefit. We present epidemiological evidence, a mechanistic explanation and a review of interventional studies for these nutrients. Finally, relevant nutritional guidelines are presented with their conclusion for the role of each nutrient in the management of depression.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
S-Adenosylmethionine
/
Tryptophan
/
Fatty Acids, Omega-3
/
Depression
Limits:
Humans
Language:
En
Journal:
Nutrients
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: