Value of serum fibrillin-1 in the diagnosis of cervicocerebral artery dissection / 中风与神经疾病杂志

ABSTRACT

@#Objective To investigate the clinical value of serum fibrillin-1(FBN-1) in the diagnosis of cervicocerebral artery dissection(CAD). Methods A total of 55 patients who were hospitalized and diagnosed with CAD in Department of Neurology in our hospital were consecutively collected as CAD group,and according to whether the time of onset was ≥15 days,they were divided into acute stage CAD group and non-acute stage CAD group;30 healthy subjects,matched for sex and age,who underwent physical examination during the same period of time were selected as control group. Demographic data and serum samples were collected from both groups;ELISA was used to measure the serum level of FBN-1,and the receiver operating characteristic(ROC) curve was plotted to analyze the value of serum FBN-1 in the diagnosis of CAD. Results There were no significant differences in age,sex,diabetes,and smoking history between the CAD group and the control group(P>0.05). There were significant differences in the incidence rates of hyperlipidemia and hypertension between the two groups(P<0.05),and the logistic regression analysis showed that hypertension was positively correlated with CAD(P<0.05) and hyperlipidemia was negatively correlated with CAD(P<0.05). The serum level of FBN-1 was(50.75±11.65)ng/ml in the CAD group,(55.81±8.98) ng/ml in the acute stage CAD group,(40.35±9.50)ng/ml in the non-acute stage CAD group,and (39.06±8.58)ng/ml in the control group,and the CAD group had a significantly higher serum level of FBN-1 than the control group(P<0.05);there was a significant difference in the serum level of FBN-1 between the acute stage CAD group and the non-acute stage CAD group and between the acute stage CAD group and the control group(P<0.001),while there was no significant difference between the non-acute stage CAD group and the control group(P>0.05). The ROC curve analysis showed that serum FBN-1 had a relatively high efficiency in the diagnosis of acute-stage CAD,with a cut-off value of 46.62 ng/ml,a sensitivity of 0.86,a specificity of 0.83,and an area under the ROC curve of 0.91(95% confidence interval:0.845-0.982,P<0.0001). Conclusion Serum FBN-1 has a certain clinical application value in the diagnosis of acute-stage CAD.