A Comparative Study of Hepatocyte Lysosomes in Six Kinds of Mammals / 第三军医大学学报

ABSTRACT

A qualitative and quantitative comparison of the ultrastructure of the hepato-cyte lysosomes of adult monkeys, dogs, cats, rabbits, rats, and mice were carried out.The dense bodies in the hepatocytes in the animals studied were similar in their ultrastructure but different in their number and size. The digestive vacuole was more numerous in rats, mice, rabbits and monkeys than in dogs and cats. But the residue body was scarcely found in rats, mice and rabbits, a little more in cats and monkeys, and quite a lot in dogs. Besides, some undigested globular substances were found just entering into the residue bodies to be digested. The difference of the digestive vacuoles and residue bodies in the hepatocytes of these mammals are probably due to the species difference and the different kinds of food eaten.In dogs and monkeys, bristle coated vesicles were formed by the budding out of the adjacent cell membrane of two hepatocytes with one end of the budding in-vaginating into the cytoplasm and the other end enlarged and pinching out.The results of morphometric analysis of lysosomes of the hepatocytes were different in the 6 kinds of mammals studied.The volume density of lysosomes of the hepatocytes was the highest in dogs and the lowest in mice, and the numerical density was the highest in monkeys and the lowest in rabbits.