Heart Transplantation. A Retrospective Analysis of the Short and Intermediate Term Results / 대한구급학회지
The Korean Journal of Critical Care Medicine
; : 23-29, 2001.
Article
in Ko
| WPRIM
| ID: wpr-644947
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Heart transplantation is still the best therapy for end-stage heart disease. However, the longterm outcome among different institutions vary. The current series is an assessment of the important factors which determine prognosis.METHODS:
Between November of 1992 and September of 2000, 85 heart transplantations were performed at our institution. The standard technique was used in the first 57 patients (group I) where as in the latter 28 patients (group II), the Bicaval technique was utilized. The mean waiting time was approximately 4.7 months, and the causes in decreasing order were Dilated cardiomyopathy (n=69), Ischemic cardiomyopathy (n=10), Hypertrophic cardiomyopathy and others (n=6). The mean follow up was about 31 months. The immunosuppressive protocol comprised cyclosporin, Azathioprine (AZA), and prednisone. Later changes included induction with IL-2 receptor monoclonal antibody and changing AZA to mycophenolate mofetil.RESULTS:
The mean donor ischemic time was 95.8 28.3 mins and the implantation time was 59.3 7.6 mins. There was a higher incidence of significant TR in group I along with a greater postoperative pacing requirement. There were 35 postoperative complications of which infectious events were most common (26). Of these, only 3 were early infections and the rest occurred late postoperatively. There were a total of 8 mortalities of which only one occurred early postoperatively and among the 7 late deaths, 3 were medically related and 4 were related to social factors. Only 5% of the patients had graft vascular disease. The overall 1YSR was 92% and the 5 YSR was 85%.CONCLUSIONS:
The superior long term results of this current series was attributable to strong early immunosuppression, a homogenous population, and very low incidence of CMV infection.Key words
Full text:
1
Database:
WPRIM
Main subject:
Postoperative Complications
/
Prognosis
/
Azathioprine
/
Tissue Donors
/
Vascular Diseases
/
Cardiomyopathy, Hypertrophic
/
Prednisone
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Cardiomyopathy, Dilated
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Receptors, Interleukin-2
/
Incidence
Type of study:
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Ko
Journal:
The Korean Journal of Critical Care Medicine
Year:
2001
Document type:
Article