Relation between ABCA1 expression and carotid atherosclerotic plaques / 中华神经科杂志
Chinese Journal of Neurology
; (12)2001.
Article
in Zh
| WPRIM
| ID: wpr-676284
Responsible library:
WPRO
ABSTRACT
Objective To investigate the changes of the expressions of ATP-binding cassette transporter A1(ABCA1)and the retinoid X receptor(RXR?in human carotid atherosclerotic plaques and to explore the possible mechanisms by which ABCA1 affects the formation of carotid atherosclerosis(CAS). Methods 24 carotid atherosclerotic plaque and 10 intestinal artery specimens were respectively collected to compared the expression levels of ABCA1 mRNA.RXR?mRNA and those protein,ABCA1 and RXR?gene expressions were determined by reverse transcriptase polymerase chain reaction(RT-PCR)in the specimens,meanwhile the presence of ABCAI and RXRcprotein was assessed by Western blot.Results ABCA1(0.79?0.04)and RXR?(0.73?0.04)gene expression were significantly elevated in carotid atherosclerotic plaques(P
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Neurology
Year:
2001
Document type:
Article