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Collimation principles of a hollow X-ray microbeam for high-contrast cytoplasm irradiation.
Cheng, Qinqin; Zhao, Ruifeng; Wang, Xiaowa; Wang, Xufei.
Affiliation
  • Cheng Q; Institute of Modern Physics, Fudan University, Shanghai 200433, China.
  • Zhao R; Key Laboratory of Nuclear Physics and Ion-beam Application (MOE), Fudan University, Shanghai 200433, China.
  • Wang X; Department of Radiation Oncology, Tongji University School of Medicine, Shanghai Pulmonary Hospital, Shanghai 200433, China.
  • Wang X; Institute of Modern Physics, Fudan University, Shanghai 200433, China.
J Radiat Res ; 65(5): 591-602, 2024 Sep 24.
Article in En | MEDLINE | ID: mdl-39154379
ABSTRACT
A Monte Carlo simulation was used to assess the performance of a collimated hollow X-ray microbeam for subcellular cytoplasm irradiation. A high-Z coaxial collimation structure with an inner core for nucleus shielding was investigated. Two key performances, the extraction efficiency (cytoplasm dose per unit incident fluence) and the dose contrast (cytoplasm-to-nucleus dose ratio), were evaluated regarding the influences of the material, geometry and physical arrangements of the collimator, target dish and incident beam source. Simulation results demonstrate that a gold coaxial structure with a practical collimation geometry of a 1-mm length, 10-µm inner diameter and 200-µm outer diameter, with the top exit closely attached (with a minimized air gap) to the bottom of a cell dish with a 3-µm thick Mylar film is recommended for cytoplasm irradiation of adherent mammalian cells. For a synchrotron source in the energy range < 10 keV, a dose contrast of approximately 100 can be achieved. For a bremsstrahlung source <30-kV tube voltage, a dose contrast of approximately 50-100 can still be achieved. General principles are summarized with further explanations of the performance of the hollow X-ray microbeam.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monte Carlo Method / Cytoplasm Limits: Animals / Humans Language: En Journal: J Radiat Res Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monte Carlo Method / Cytoplasm Limits: Animals / Humans Language: En Journal: J Radiat Res Year: 2024 Document type: Article Affiliation country: Country of publication: