Association between polyunsaturated fatty acids and inflammatory markers in patients in secondary prevention of cardiovascular disease
Nutrition
; 37(May): 30-36, 2017. tab
Article
de En
| SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1064964
Bibliothèque responsable:
BR79.1
Localisation: BR79.1
ABSTRACT
OBJECTIVE:
The aim of this study was to assess the association between polyunsaturated fatty acids (PUFAs) and inflammatory biomarkers among patients in secondary prevention of cardiovascular disease (CVD).METHODS:
In this cross-sectional substudy from BALANCE Program Trial, we have collected data from 364 patients with established CVD. Twenty-four-hour dietary recalls and plasma FA concentrations were analyzed to estimate the FA intake. Inflammatory biomarkers measurement consisted of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, C-reactive protein, adiponectin, and tumor necrosis factor-α. After log-transformation of inflammatory biomarkers, multivariate-adjusted general linear model was used to examine the effect of FA intake. The association was adjusted for body mass index, waist circumference, energy, smoking status, age, total cholesterol, low-density lipoprotein cholesterol, physical activity, and calcium channel blockers.RESULTS:
PUFAs were inversely associated with C-reactive protein levels (P = 0.006) and with IL-1 β. The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 β...
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Collection:
06-national
/
BR
Base de données:
SES-SP
/
SESSP-IDPCPROD
Sujet principal:
Maladies cardiovasculaires
/
Inflammation
Type d'étude:
Prognostic_studies
/
Risk_factors_studies
Langue:
En
Journal:
Nutrition
Année:
2017
Type de document:
Article