The translational challenge in Chagas disease drug development
Mem. Inst. Oswaldo Cruz
; 117: e200501, 2022. graf
Article
de En
|
LILACS-Express
| LILACS
| ID: biblio-1375909
Bibliothèque responsable:
BR1.1
ABSTRACT
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.
Texte intégral:
1
Collection:
01-internacional
Base de données:
LILACS
Type d'étude:
Prognostic_studies
Langue:
En
Journal:
Mem. Inst. Oswaldo Cruz
Sujet du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2022
Type de document:
Article
/
Project document
Pays d'affiliation:
Brésil
/
Suisse