Dysarthria in hereditary spastic paraplegia type 4
Clinics
; 78: 100128, 2023. tab
Article
de En
|
LILACS-Express
| LILACS
| ID: biblio-1421267
Bibliothèque responsable:
BR1.1
ABSTRACT
Abstract Objective:
To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated it with their clinical data.Methods:
Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the study the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched for sex and age. The speech assessment of both groups included speech task recording, acoustic analysis, and auditory-perceptual analysis. In addition, disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS).Results:
In the auditory-perceptual analysis, 53.5% (n = 15) of individuals with SPG4 were dysarthric, with mild to moderate changes in the subsystems of phonation and articulation. On acoustic analysis, SPG4 subjects' performances were worse in measurements related to breathing (maximum phonation time) and articulation (speech rate, articulation rate). The articulation variables (speech rate, articulation rate) are related to the age of onset of the first motor symptom.Conclusion:
Dysarthria in SPG4 is frequent and mild, and it did not evolve in conjunction with more advanced motor diseases. This data suggest that diagnosed patients should be screened and referred for speech therapy evaluation and those pathophysiological mechanisms of speech involvement may differ from the length-dependent degeneration of the corticospinal tract.
Texte intégral:
1
Collection:
01-internacional
Base de données:
LILACS
Type d'étude:
Observational_studies
Langue:
En
Journal:
Clinics
Sujet du journal:
MEDICINA
Année:
2023
Type de document:
Article
/
Project document
Pays d'affiliation:
Brésil
Pays de publication:
Brésil