Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study
Clin. transl. oncol. (Print)
; 13(10): 747-753, oct. 2011. tab, ilus
Article
de En
| IBECS
| ID: ibc-125931
Bibliothèque responsable:
ES1.1
Localisation: BNCS
ABSTRACT
BACKGROUND The purpose of this study was to evaluate telomerase activity in peripheral whole blood from head and neck squamous cell carcinoma (HNSCC) patients as a biomarker for diagnosis of HNSCC or detection of recurrence during follow-up. MATERIALS AND METHODS Telomerase activity was measured from peripheral whole blood extracts by telomerase repeat amplification protocol (TRAP) in HNSCC patients before and after surgery and in a control group. Sixty-two HNSCC patients and 42 control subjects were included. RESULTS Telomerase activity was found in 41 out of 62 (66.1%) HNSCC patients before surgery and in 8 out of 42 (19.0%) controls (p<0.001). Among 41 HNSCC patients who showed positive telomerase activity before surgery, 32 (78.1%) showed a conversion of telomerase activity to negative after surgery. In follow-up, 6 out of 8 (75%) showed conversion of telomerase activity from negative to positive after recurrence. Telomerase activity was changed to negative in 4 out of 6 (66%) recurred patients with positive telomerase activity after second surgery. CONCLUSION The telomerase activity in peripheral whole blood extracts of HNSCC patients might be a useful biomarker for detecting recurrence after treatment. Further study with larger sample size using a more sensitive detection method of telomerase activity is necessary to verify these results (AU)
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Collection:
06-national
/
ES
Base de données:
IBECS
Sujet principal:
Marqueurs biologiques tumoraux
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Études cas-témoins
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Tumeurs épidermoïdes
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Telomerase
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Tumeurs de la tête et du cou
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Récidive tumorale locale
Type d'étude:
Guideline
/
Observational_studies
/
Prognostic_studies
Limites:
Adult
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Aged
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Female
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Humans
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Male
Langue:
En
Journal:
Clin. transl. oncol. (Print)
Année:
2011
Type de document:
Article