Stereotactic body radiation therapy (SBRT) delays the emergence of castration resistance in patients with oligometastatic prostate cancer
Clin. transl. oncol. (Print)
; 18(7): 743-747, jul. 2016. ilus, graf
Article
de En
| IBECS
| ID: ibc-153501
Bibliothèque responsable:
ES1.1
Localisation: BNCS
ABSTRACT
Purpose:
To investigate whether bone metastases-directed stereotactic body radiation therapy (SBRT) delays the emergence of castration resistance in patients with oligometastatic prostate cancer (OPC). Methods andmaterial:
OPC is usually managed with androgen deprivation therapy (ADT). Migration to castration-resistant prostate cancer will inevitably occur in the majority of these patients. There are several strategies aimed to delay the emergence of castration resistance including intermittent ADT, second generation antiandrogens (abiraterone, enzalutamide) or metastases-directed SBRT. The present report describes two cases of patients with OPC that received SBRT 24 Gy/3Rx to the solitary bony lesion after ADT failure.Results:
Both cases showed complete and durable biochemical response for 13 and 17 months, respectively.Conclusions:
SBRT can be used to delay the emergence of castration resistance and the need for systemic therapy when used after ADT failure (AU)RESUMEN
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Collection:
06-national
/
ES
Base de données:
IBECS
Sujet principal:
Tumeurs de la prostate
/
Tumeurs prostatiques résistantes à la castration
/
Métastase tumorale
Limites:
Humans
/
Male
Langue:
En
Journal:
Clin. transl. oncol. (Print)
Année:
2016
Type de document:
Article