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Does Sugammadex Suppress Allergic Inflammation Due to Rocuronium in Animal Model of Rat?
Yeşiltaş, Serdar; Orhon, Zeynep Nur; Cakir, Hasan; Dogru, Mahmut; Güra Çelik, Melek.
Affiliation
  • Yeşiltaş, Serdar; Bezmialem Vakıf University Medical Faculty Department of Anesthesiology and Reanimation. Istanbul. Turkey
  • Orhon, Zeynep Nur; Medeniyet University Medical Faculty Department of Anesthesiology and Reanimation. Istanbul. Turkey
  • Cakir, Hasan; Department of Anesthesiology and Reanimation. Ozel Yasam Hospital. Batman. Turkey
  • Dogru, Mahmut; Department of PediatricAllergy-Immunology. Memorial Sisli Hospita. Istanbul. Turkey
  • Güra Çelik, Melek; Medeniyet University Medical Faculty Department of Anesthesiology and Reanimation. Istanbul. Turkey
Allergol. immunopatol ; 49(3): 91-99, mayo 2021. ilus, tab
Article de En | IBECS | ID: ibc-214269
Bibliothèque responsable: ES1.1
Localisation: ES15.1 - BNCS
ABSTRACT
Introduction and

Objectives:

There are a few reports in the literature about the successful use of sugammadex in the treatment of hypersensitivity reactions caused by rocuronium; however, the pathophysiological mechanism is still unknown. This study aims to investigate the changes caused by rocuronium in the lung and the effect of sugammadex on these changes with biochemical, light microscopic and immunohistochemical parameters on a rat model. Materials and

Methods:

For the study, 28-male Sprague-Dawley rats were randomly divided, seven of each, into four groups. Group C (control) received only 0. 9 % NaCl without any drug. Group R received rocuronium alone 1mg/kg. Group S received sugammadex alone 96 mg/kg. Group RS received rocuronium 1mg/kg and sugammadex 96 mg/kg. After 24 h later, the animals were sacrificed and their tissues were removed. Biochemical (IgE/CRP), light microscopic and immunohistochemical findings were recorded.

Results:

Immunoglobulin E and CRP levels, peribronchial, alveolar septal lymphocytic infiltration, thickening of the alveolar membranes and bleeding sites in Group R were significantly higher than all the other groups. In Group RS, while these parameters were significantly lower than that of Group R and Group S, it was significantly higher than that of Group C. Total mast cells and tryptase-positive mast cells counts were significantly higher in Group R than in all other groups. In Group RS, these parameters were statistically lower than that of Group R and Group S, but higher than that of Group C.

Conclusions:

This study shows that allergic inflammatory changes due to rocuronium in the lungs of rats are reduced with sugammadex. These results support cases of anaphylaxis due to rocuronium which improved with sugammadex (AU)
Sujet(s)
Mots clés

Texte intégral: 1 Collection: 06-national / ES Base de données: IBECS Sujet principal: Sugammadex / Rocuronium / Hypersensibilité / Inflammation / Poumon / Curarisants dépolarisants Limites: Animals Langue: En Journal: Allergol. immunopatol Année: 2021 Type de document: Article

Texte intégral: 1 Collection: 06-national / ES Base de données: IBECS Sujet principal: Sugammadex / Rocuronium / Hypersensibilité / Inflammation / Poumon / Curarisants dépolarisants Limites: Animals Langue: En Journal: Allergol. immunopatol Année: 2021 Type de document: Article