Risk of endometrial cancer after RRSO in BRCA 1/2 carriers: a multicentre cohort study / Riesgo de cáncer de endometrio después de RRSO en portadoras de BRCA 1/2: un estudio de cohorte multicéntrico
Clin. transl. oncol. (Print)
; 26(4): 1033-1037, Abr. 2024.
Article
de En
| IBECS
| ID: ibc-VR-66
Bibliothèque responsable:
ES1.1
Localisation: ES15.1 - BNCS
ABSTRACT
Objective:
To know the risk of endometrial cancer (EC) in a population of women with BRCA 1/2 pathogenic or likely pathogenic variants after risk-reducing salpingo-oophorectomy (RRSO).Methods:
The study cohort included data from 857 women with BRCA mutations who underwent RRSO visited four hospitals in Catalonia, Spain, from January 1, 1999 to April 30, 2019. Standardized incidence ratio (SIR) of EC was calculated in these patients using data from a regional population-based cancer registry.Results:
After RRSO, eight cases of EC were identified. Four in BRCA 1 carriers and four in BRCA2 carriers. The expected number of cases of EC was 3.67 cases, with a SIR of 2.18 and a 95% CI (0.933.95).Conclusions:
In our cohort, the risk of EC in BRCA1/2 carriers after RRSO is not greater than expected. Hysterectomy is not routinely recommended for these patients.(AU)Mots clés
Texte intégral:
1
Collection:
06-national
/
ES
Base de données:
IBECS
Sujet principal:
Ophtalmologie
/
Douleur
/
Tumeurs du pancréas
/
Soins postopératoires
/
Période postopératoire
/
Complications de la grossesse
/
Soins de santé primaires
/
Recherche
/
Fibrillation auriculaire
/
Infractions sexuelles
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Aspects:
Determinantes_sociais_saude
/
Patient_preference
Limites:
Humans
/
Female
/
Male
/
Aged
/
Adolescent
/
Child
/
Newborn
Pays/Région comme sujet:
Europa
/
Africa
Langue:
En
/
Es
Journal:
Rev. esp. cir. ortop. traumatol. (Ed. impr.)
/
An. pediatr. (2003. Ed. impr.)
/
Aten. prim. (Barc., Ed. impr.)
/
Clin. transl. oncol. (Print)
/
Clín. investig. ginecol. obstet. (Ed. impr.)
/
Enferm. infecc. microbiol. clín. (Ed. impr.)
/
Gastroenterol. hepatol. (Ed. impr.)
/
Int. microbiol
/
Interv. psicosoc. (Internet)
/
Med. clín (Ed. impr.)
Année:
2022
/
2023
/
2021
/
2024
Type de document:
Article