A negative iodine balance is found in healthy neonates compared with neonates with thyroid agenesis.
J Endocrinol
; 161(1): 115-20, 1999 Apr.
Article
de En
| MEDLINE
| ID: mdl-10194535
ABSTRACT
We studied the effects of the presence or absence of the thyroid gland on the iodine metabolism and excretion in term Dutch newborns by performing a retrospective study of the urinary iodine excretion in 193 term newborns with abnormal congenital hypothyroidism screening results. Thirty-six euthyroid newborns with decreased thyroxine-binding globulin levels were compared with 157 hypothyroid patients, 54 due to thyroid agenesis and 103 due to thyroid dysgenesis. A significant difference in the urinary iodine excretion was observed between the agenesis group (mean 28 micrograms/24 h) and the euthyroid newborns (mean 46 micrograms/24 h, P=0.001). In conclusion, healthy, euthyroid, term newborns excreted more iodine in their urine than newborns with thyroid agenesis. These results strongly indicated the existence of a temporarily negative iodine balance the excretion of iodine prevailed over the intake and the newborn's thyroidal iodine, stored during pregnancy, could be used for thyroxine synthesis in the postnatal period. Since healthy term neonates were able to maintain adequate plasma free thyroxine concentrations under normal TSH stimulation, the prenatally acquired iodine stores could be considered sufficiently high to compensate for the transient postnatal losses.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Glande thyroide
/
Nouveau-né
/
Iode
Type d'étude:
Observational_studies
Limites:
Female
/
Humans
/
Male
Langue:
En
Journal:
J Endocrinol
Année:
1999
Type de document:
Article
Pays d'affiliation:
Pays-Bas