Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog.
J Ethnopharmacol
; 64(2): 127-33, 1999 Feb.
Article
de En
| MEDLINE
| ID: mdl-10197747
ABSTRACT
The vegetal species Pterodon emarginatus Vog. (Leguminosae/Papilonaceae), popularly known in Brazil as 'sucupira branca', is widely used by domestic medicine as an anti-inflammatory. From these observations, the hexanic crude extract (HCE) of the fruits was obtained and submitted for assessment of its anti-inflammatory activity. For this purpose, the following tests were used (1) Determination of ED50 and LD50; (2) Paw edema induced by carrageenin, dextran, histamine and nystatin; (3) Peritonitis caused by carrageenin and (4) Granuloma test. The ED50 (oral) in the edema induced by carrageenin was 500 mg/kg, and LD50 (oral) was 4.02 g/kg. In the edema caused by nystatin, there was a significant inhibition by 45% (P < 0.05 student's t-test) at the 6th hour following the treatment. In the granuloma test performed in animals treated with HCE, there was an inhibition of the granulomatous tissue formation by 22%. The migration of neutrophils towards the peritoneal cavity was inhibited in HCE treated animals by 43% (P < 0.05). However, in the edema caused by dextran and histamine, there was no significant response in HCE treated animals.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plantes médicinales
/
Oedème
/
Fabaceae
/
Anti-inflammatoires
Limites:
Animals
Langue:
En
Journal:
J Ethnopharmacol
Année:
1999
Type de document:
Article
Pays d'affiliation:
Brésil