High prevalence of GB virus C in Brazil and molecular evidence for intrafamilial transmission.
J Clin Microbiol
; 37(5): 1634-7, 1999 May.
Article
de En
| MEDLINE
| ID: mdl-10203545
ABSTRACT
The prevalence of GB virus C (GBV-C) in candidate Brazilian blood donors with normal and elevated alanine aminotransferase levels was found to be 5.2% (5 of 95) and 6.5% (5 of 76), respectively. Among Brazilian patients, GBV-C was found in 9.5% (13 of 137) of cases of hepatitis not caused by hepatitis A virus (HAV), HBV, HCV, HDV, or HEV (non-A-E hepatitis) and in 18.2% (8 of 44) of individuals infected with HCV. Molecular characterization of GBV-C by partial sequencing of the NS3 region showed clustering between members of a single family, implying intrafamilial transmission. In conclusion, these results together suggest that contagion mechanisms which facilitate intrafamilial transmission of GBV-C may partially explain the high prevalence of viremic carriers worldwide.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Flaviviridae
/
Hépatites virales humaines
Type d'étude:
Prevalence_studies
/
Risk_factors_studies
Limites:
Humans
Pays/Région comme sujet:
America do sul
/
Brasil
Langue:
En
Journal:
J Clin Microbiol
Année:
1999
Type de document:
Article
Pays d'affiliation:
Brésil