Effects of long-term intake of retinol on selected clinical and laboratory indexes.
Am J Clin Nutr
; 69(5): 937-43, 1999 May.
Article
de En
| MEDLINE
| ID: mdl-10232634
ABSTRACT
BACKGROUND:
Chemopreventive agents developed to be used in a moderate-risk but otherwise healthy population need to be both efficacious and to have minimal adverse effects.OBJECTIVE:
The objective of this study was to evaluate the adverse effects of long-term retinol intake in a skin cancer chemoprevention trial in a large population at moderate risk for skin cancer.DESIGN:
Participants (n = 2297) were randomly assigned to receive retinol [7576 retinol equivalents (RE), or 25000 IU] or a placebo daily. The adverse effects of retinol intake were studied by monitoring 14 clinical symptoms and laboratory indexes. The median follow-up time was 3.8 y.RESULTS:
No adverse effects concerning the 14 symptoms were observed. Significant differences in alkaline phosphatase (P < 0.0001), triacylglycerol (P < 0.0001), cholesterol (P = 0.04), and HDL (P = 0.01) were observed over time between the 2 groups. After 49 mo of follow-up, alkaline phosphatase was 7% higher, triacylglycerol was 11% higher, cholesterol was 3% higher, and HDL was 1% lower in the retinol group than in the placebo group.CONCLUSIONS:
Because a 1% increase in cholesterol concentrations has been reported to be associated with a 2% increase in coronary artery disease risk, long-term ingestion of 7576 RE vitamin A/d should be considered with caution. However, further studies are needed to confirm this finding.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Photodermatoses
/
Rétinol
Type d'étude:
Clinical_trials
Limites:
Aged
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Am J Clin Nutr
Année:
1999
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique