Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.
Nat Genet
; 22(1): 37-43, 1999 May.
Article
de En
| MEDLINE
| ID: mdl-10319859
ABSTRACT
Cre-mediated excision of exon 11 of the breast-tumour suppressor gene Brca1 in mouse mammary epithelial cells causes increased apoptosis and abnormal ductal development. Mammary tumour formation occurs after long latency and is associated with genetic instability characterized by aneuploidy, chromosomal rearrangements or alteration of Trp53 (encoding p53) transcription. To directly test the role of p53 in Brca1-associated tumorigenesis, we introduced a Trp53-null allele into mice with mammary epithelium-specific inactivation of Brca1. The loss of p53 accelerated the formation of mammary tumours in these females. Our results demonstrate that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs mammaires de l'animal
/
Protéine BRCA1
/
Cellules épithéliales
/
Glandes mammaires animales
Limites:
Animals
Langue:
En
Journal:
Nat Genet
Sujet du journal:
GENETICA MEDICA
Année:
1999
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique