Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis.
Mult Scler
; 5(2): 134-6, 1999 Apr.
Article
de En
| MEDLINE
| ID: mdl-10335523
ABSTRACT
We have used a PCR based method to analyze allelic frequencies in a (TG)n(AG)m microsatellite marker located in the first intron of the apolipoprotein C-II gene in French MS patients and controls. Samples were collected from 74 MS patients and from 102 controls. The distribution of microsatellite alleles differed between patients and controls (chi 2 = 7.82), showing a significant effect (P < 0.04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P < 0.03) of allele I. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Apolipoprotéines C
/
Chromosomes humains de la paire 19
/
Liaison génétique
/
Sclérose en plaques
Type d'étude:
Risk_factors_studies
Limites:
Humans
Langue:
En
Journal:
Mult Scler
Sujet du journal:
NEUROLOGIA
Année:
1999
Type de document:
Article
Pays d'affiliation:
France