1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.

Jeppesen, L; Olesen, P H; Hansen, L; Sheardown, M J; Thomsen, C; Rasmussen, T; Jensen, A F; Christensen, M S; Rimvall, K; Ward, J S; Whitesitt, C; Calligaro, D O; Bymaster, F P; Delapp, N W; Felder, C C; Shannon, H E; Sauerberg, P

Jeppesen, L; Olesen, P H; Hansen, L; Sheardown, M J; Thomsen, C; Rasmussen, T; Jensen, A F; Christensen, M S; Rimvall, K; Ward, J S; Whitesitt, C; Calligaro, D O; Bymaster, F P; Delapp, N W; Felder, C C; Shannon, H E; Sauerberg, P.

Affiliation

Jeppesen L; Novo Nordisk A/S, Health Care Discovery, Novo Nordisk Park, DK-2760 Mâlov, Denmark.

J Med Chem ; 42(11): 1999-2006, 1999 Jun 03.

Article de En | MEDLINE | ID: mdl-10354408

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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Composés aza / Thiadiazoles / Récepteur muscarinique / Agonistes muscariniques / Heptanes Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 1999 Type de document: Article Pays d'affiliation: Danemark

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