Thoracic epidural anesthesia as an adjunct to general anesthesia for cardiac surgery: effects on ventilation-perfusion relationships.
J Cardiothorac Vasc Anesth
; 13(3): 258-64, 1999 Jun.
Article
de En
| MEDLINE
| ID: mdl-10392674
ABSTRACT
OBJECTIVE:
To determine the effects of thoracic epidural anesthesia (TEA) on ventilation-perfusion (VA/Q) relationships, atelectasis, and oxygenation before and after coronary artery bypass graft surgery (CABG).DESIGN:
Prospective, controlled, unblinded, randomized trial.SETTING:
Cardiothoracic clinic at a major university referral center.PARTICIPANTS:
Twenty-eight patients undergoing elective CABG.INTERVENTIONS:
Perioperative and postoperative TEA was added to general anesthesia (GA) in 14 patients, and 14 patients receiving GA alone served as controls. MEASUREMENTS AND MAINRESULTS:
VA/Q relationships were measured by the multiple inert gas elimination technique, and, 20 hours postoperatively, atelectasis was assessed by computerized tomographic scans. Arterial and mixed venous blood gases and hemodynamic variables were measured by standard techniques. TEA per se caused no change in shunt, VA/Q matching, or oxygenation. Induction of GA in the control group and induction of TEA caused similar reductions in mean arterial pressure. The TEA patients needed less morphine analgesia postoperatively and were extubated earlier. Extubation caused significant improvement in VA/Q matching. On the first postoperative day, a slight reduction in PaCO2 was seen in the TEA group, but no differences in shunt, VA/Q matching, or oxygenation compared with the GA group. Both groups showed extensive bilateral atelectasis.CONCLUSION:
TEA can reduce respirator time and the need for morphine analgesics after CABG without negative effects on VA/Q matching, oxygenation, or atelectasis formation.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Rapport ventilation-perfusion
/
Pontage aortocoronarien
/
Anesthésie péridurale
/
Anesthésie générale
Type d'étude:
Clinical_trials
/
Etiology_studies
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Cardiothorac Vasc Anesth
Sujet du journal:
ANESTESIOLOGIA
/
CARDIOLOGIA
Année:
1999
Type de document:
Article
Pays d'affiliation:
Suède