Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).

Fryatt, T; Goroski, D T; Nilson, Z D; Moody, C J; Beall, H D

Fryatt, T; Goroski, D T; Nilson, Z D; Moody, C J; Beall, H D.

Affiliation

Fryatt T; School of Chemistry, University of Exeter, Devon, UK.

Bioorg Med Chem Lett ; 9(15): 2195-8, 1999 Aug 02.

Article de En | MEDLINE | ID: mdl-10465544

ABSTRACT

ABSTRACT

The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)Hquinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.

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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Quinolinone / NADH, NADPH oxidoreductases / Antinéoplasiques Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 1999 Type de document: Article Pays d'affiliation: Royaume-Uni

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