On the inhibitory activities of a new boron compound and ultrasound against the mouse ascites tumour.
Chemotherapy
; 45(5): 360-9, 1999.
Article
de En
| MEDLINE
| ID: mdl-10473924
ABSTRACT
The inhibitory effects of a new boron compound, dihydroxy (oxybiguanido) boron (III) hydrochloride monohydrate (HB), and ultrasound (US) of a frequency 25 kHz on the growth of ascites tumour in female Swiss mice were studied by monitoring the survival, weight of tumour-associated material, tumour cell count, serum alkaline phosphatase activity and the haematological parameters of the treated animals. 5-Fluorouracil (5-FU), a well-known anticancer agent, was used as positive control. While HB exhibited a very significant antitumour action, US alone produced a small but significant inhibitory effect. The combination of US with HB or 5-FU produced an extra antitumour action as compared to the actions of these chemicals used singly. The mechanisms of action of the new boron compound (HB) and US are discussed.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ultrasonothérapie
/
Composés du bore
/
Carcinome d'Ehrlich
/
Antinéoplasiques
Limites:
Animals
Langue:
En
Journal:
Chemotherapy
Année:
1999
Type de document:
Article
Pays d'affiliation:
Inde