Tc-99m-labeling of modified RNA.
Nucleosides Nucleotides
; 18(6-7): 1479-81, 1999.
Article
de En
| MEDLINE
| ID: mdl-10474227
ABSTRACT
The synthesis of Tc-99m-labeled, modified RNA is reported. This new class of radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified ON's. The N3S-RNA was Tc-99m-labeled with 90-95% radiochemical yield and specific activities of 37MBq/nmol leading to 11-Tc-99m-N3S-aptamers.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
ARN
/
Composés organiques du technétium
/
Radiopharmaceutiques
Langue:
En
Journal:
Nucleosides Nucleotides
Année:
1999
Type de document:
Article