Variants of NOS1, NOS2, and NOS3 genes in asthmatics.
Biochem Biophys Res Commun
; 267(3): 761-3, 2000 Jan 27.
Article
de En
| MEDLINE
| ID: mdl-10673365
ABSTRACT
Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n = 300). Intragenic microsatellite variants of NOS1 were significantly associated with asthma [odds ratio (OR) = 2.08, 95% CI 1.20-3.57 (95% CI), P = 0.008 (Pc = 0.048)], but not with IgE levels. Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels. These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Asthme
/
Variation génétique
/
Nitric oxide synthase
Type d'étude:
Clinical_trials
/
Prognostic_studies
Limites:
Humans
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Biochem Biophys Res Commun
Année:
2000
Type de document:
Article
Pays d'affiliation:
Royaume-Uni